Antibacterial nanoparticles with pH-triggered release for personalized treatment of infected burns

This project addresses the challenge of treating burn wounds complicated by antibiotic-resistant bacteria, such as MRSA. Traditional approaches, like antibiotic dressings and skin grafts, often fail against resistant strains, emphasizing the need for innovative therapies. To tackle this, the project focuses on developing advanced biomaterials featuring copper nanoparticles (CuNPs) stabilized by chitosan, designed for pH-controlled release in the alkaline conditions of infected wounds. These CuNPs provide strong antimicrobial activity against diverse bacteria while supporting tissue regeneration. Embedded in carboxymethyl cellulose hydrogels, the system enables moist wound healing and infection-responsive drug release, offering a promising solution for managing infected burn wounds and combating antibiotic resistance.